| 急性肾炎患儿尿微量白蛋白,Kappa轻链与临床关系的研究 |
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| 引用本文： | 龚红蕾,黄锋,蒋晓天,孙宝兰.急性肾炎患儿尿微量白蛋白,Kappa轻链与临床关系的研究[J].南通医学院学报,2011,31(1):43-45. |
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| 作者姓名： | 龚红蕾 黄锋 蒋晓天 孙宝兰 |
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| 作者单位： | 南通大学附属医院儿科,南通,226001 |
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| 摘 要： | 目的：研究急性肾炎患儿尿微量白蛋白（ALB）、Kappa轻链与临床之间的关系,寻找新的肾损害敏感无创伤指标。方法：分别使用尿ALB酶免疫法一步法和闪射比蚀法检测临床收集的标本中的尿ALB、Kappa轻链、Lambda轻链的含量,研究急性肾炎患儿尿AlB,Kappa轻链急性期、恢复期与对照组的比较以及与临床的关系。结果：急性肾炎患儿尿ALB急性期与恢复期及对照组比较差异有统计学意义（P〈0.01）;尿ALB恢复期与对照组比较差异无统计学意义（P〉0.05）;ALB急性肾炎患儿尿Kappa链急性期与恢复期及对照组比较差异有统计学意义（P〈0.01）;尿Kappa链恢复期与对照组比较差异无统计学意义（P〉0.05）;急性肾炎患儿Lambda链急性期、恢复期与对照组比较差异无统计学意义（P〉0.05）。急性肾炎患儿尿ALB与补体C3、C4、血尿在统计学上无相关性（R=0.186、0.032、0.128,P〉0.05）,ALB与尿蛋白有正相关（R=0.71,P〈0.05）。尿Kappa链与补体C3、C4、血尿在统计学上无相关性（R=0.023、0.01、0.21,P〉0.05）,与蛋白尿呈正相关（R=0.69,P〈0.05）。结论：急性肾炎患儿尿ALB、Kappa轻链可作为新的肾损伤敏感无创伤指标,早期发现及早干预,对肾炎的预后具有重要意义。
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| 关 键 词： | 急性肾炎 微量白蛋白 Kappa轻链 小儿 |
Research on the relationship among urine ALB,Kappa light chain and clinical features in acute nephritis children |
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| GONG Honglei,HUANG Feng,JIANG Xiaotian,SUN Baolan.Research on the relationship among urine ALB,Kappa light chain and clinical features in acute nephritis children[J].ACTA Academiae Medicinae Nantong,2011,31(1):43-45. |
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| Authors: | GONG Honglei HUANG Feng JIANG Xiaotian SUN Baolan |
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| Institution: | GONG Honglei,HUANG Feng,JIANG Xiaotian,SUN Baolan (Department of Pediatrics,Affiliated Hospital of Nantong University,Nantong 226001) |
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| Abstract: | Objective:To study the relationship among urine ALB,KAPPA light chain and clinical features in acute nephritis children and find a new non-invasive index sensitive to kidney damage.Methods:The content of urine ALB,Kappa light chain and lambda light chain of the collected specimens was tested with urinary ALB(albumin) and one-step enzyme immunoassay and Shanshe assay respectively,to research their urine ALB,Kappa light chain at acute stage and convalescence and their relationship with the clinical features a... |
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| Keywords: | acute nephritis urine albumin Kappa light chain child |
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