Effect of spermine on acetylation of histones in rabbit heart. |
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Authors: | Amos Casti,Rosetta Dall asta,Carlo Cl? |
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Affiliation: | Istituto di Chimica Biologica, Università degli Studi di Parma, Parma, Italy |
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Abstract: | Incorporation of [14C]acetate was used as an index of acetylation of histone fractions in rabbit hearts. Spermine (10?6 and 10?5m) enhanced acetylation of all histone fractions in myocardial purified nuclei. In perfused hearts, spermine increased acetylation only in arginine-rich histone fractions. During the early stage of myocardial hypertrophy, a condition associated with a rise in the spermine content in the heart, an increased incorporation of [14C]acetate into F2a2 and F2a1 histone fractions was observed. From the results, a possible role of spermine in the mechanism of gene derepression is postulated. |
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Keywords: | Purified nuclei Perfused heart Myocardial hypertrophy Histones argininerich Spermine |
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