Ischemia-modified albumin in pregnancy |
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Authors: | Alberto Rossi Nadia Bortolotti Sara Vescovo Irene Romanello Leonardo Forzano Ambrogio Pietro Londero Guido Ambrosini Diego Marchesoni Francesco Curcio |
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Institution: | 1. Obstetrics and Gynecology Department, University Hospital of Udine, Udine, Italy;2. Clinical Analysis Institute, University Hospital of Udine, Udine, Italy;3. Department of Obstetrics and Gynecology, University of Padua, Italy |
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Abstract: | ObjectiveIn normal pregnancies, a hypoxic intrauterine environment seems necessary for early trophoblast development. In this context, maternal serum levels of ischemia-modified albumin (IMA) are elevated, reflecting the oxidative stress associated with placental development. The aim of this study was to evaluate IMA and pregnancy-associated plasma protein A (PAPP-A) in mothers bearing small-for-gestational-age (SGA) fetuses compared to normal pregnancies.Study designA prospective study was performed between June 2010 and June 2011. Serum total albumin, IMA and PAPP-A concentrations were determined in 81 pregnant women in three different periods: 1st trimester, 2nd trimester and postpartum. Two groups of subjects were retrospectively identified: Group (1) mothers bearing appropriate-for-gestational-age (AGA) fetuses, and Group (2) mothers bearing SGA fetuses. Serum total albumin and IMA concentrations were determined in 198 non-pregnant women as controls.ResultsSerum IMA concentrations increase during gestation. IMA/albumin serum levels in the 1st trimester were significantly higher in subjects of Group (2) (p < 0.05), whereas values of serum PAPP-A MoM were significantly lower (p < 0.05).ConclusionsElevated IMA serum levels together with low levels of PAPP-A were detected in the 1st trimester in mothers bearing SGA fetuses, and this may reflect early placental changes occurring before clinical manifestation of SGA. |
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Keywords: | Ischemia-modified albumin Trophoblast development Fetal growth restriction Oxidative stress |
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