Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia |
| |
Authors: | Ga Hyun Son Ja Young Kwon Sanghoo Lee Jimyeong Park Young-Jin Kim Bohyon Yun Jung Hwa Park |
| |
Affiliation: | 1. Division of Maternal-Fetal Medicine, Institute of Women''s Life Medical Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea;2. Department of Bioanalytical and Mass Spectrometry, Seoul Medical Science Institute & Seoul Clinical Laboratories, Seoul, Republic of Korea |
| |
Abstract: | ObjectiveTo compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia.Study designIn a case control study we collected serum and urine specimens from women with normal pregnancy (n = 30) and from women with severe preeclampsia (n = 43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients.ResultsBoth serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group.ConclusionThe positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage. |
| |
Keywords: | Kidney Severe preeclampsia Urinary nephrin |
本文献已被 ScienceDirect 等数据库收录! |
|