Starvation ketoacidosis in pregnancy |
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| Authors: | Charlotte J Frise Lucy Mackillop Karen Joash Catherine Williamson |
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| Institution: | 1. John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom;2. Hillingdon Hospital, Hillingdon Hospitals NHS Foundation Trust, London, United Kingdom;3. Queen Charlotte''s and Chelsea Hospital, Imperial College Healthcare NHS Trust, Imperial College London, London, United Kingdom |
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| Abstract: | Starvation ketosis outside pregnancy is rare and infrequently causes a severe acidosis. Placental production of hormones, including glucagon and human placental lactogen, leads to the insulin resistance that is seen in pregnancy, which in turn increases susceptibility to ketosis particularly in the third trimester. Starvation ketoacidosis in pregnancy has been reported and is usually precipitated by a period of severe vomiting. Ketoacidosis is likely to have important implications for fetal survival as ketoacidosis in women with type 1 diabetes mellitus is associated with intrauterine death. |
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| Keywords: | Starvation Ketoacidosis Pregnancy Metabolic acidosis High anion gap |
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