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In Vivo Vascular Wall Shear Rate and Circumferential Strain of Renal Disease Patients |
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| Authors: | Dae Woo Park Grant H Kruger Jonathan M Rubin James Hamilton Paul Gottschalk Robert E Dodde Albert J Shih William F Weitzel |
| Institution: | ∗ Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;† Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA;‡ Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA;§ Department of Radiology, University of Michigan, Ann Arbor, MI, USA;‖ Epsilon Imaging, Inc., Ann Arbor, MI, USA;¶ Veteran''s Administration Hospital, Ann Arbor, Michigan |
| Abstract: | This study measures the vascular wall shear rate at the vessel edge using decorrelation based ultrasound speckle tracking. Results for nine healthy and eight renal disease subjects are presented. Additionally, the vascular wall shear rate and circumferential strain during physiologic pressure, pressure equalization and hyperemia are compared for five healthy and three renal disease subjects. The mean and maximum wall shear rates were measured during the cardiac cycle at the top and bottom wall edges. The healthy subjects had significantly higher mean and maximum vascular wall shear rate than the renal disease subjects. The key findings of this research were that the mean vascular wall shear rates and circumferential strain changes between physiologic pressure and hyperemia that was significantly different between healthy and renal disease subjects. |
| Keywords: | Ultrasound decorrelation based velocity estimation Vascular wall shear rate Vascular circumferential strain Chronic kidney disease End stage renal disease |
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