Reduced alpha and exaggerated theta power during the resting-state EEG in fragile X syndrome |
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| Authors: | Melle J.W. Van der Molen Maurits W. Van der Molen |
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| Affiliation: | 1. Leiden University, Institute of Psychology, The Netherlands;2. Leiden Institute for Brain and Cognition, Leiden University, The Netherlands;3. Developmental Psychology Section, Department Psychology, University of Amsterdam, The Netherlands |
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| Abstract: | This study characterizes the resting-state EEG in males with fragile X syndrome to reveal abnormalities in oscillatory brain dynamics. Analyses of the eyes-closed EEG epochs showed that the resting-state EEG in FXS can be characterized by elevated relative theta power (4–8 Hz) and reduced relative upper-alpha power (10–12 Hz). Although preliminary, these findings suggest that the well-documented imbalance in excitatory/inhibitory cortical circuit activity in FXS can be revealed the level of oscillatory behavior at the scalp. A next step for future studies is linking the EEG resting-state indices to cognitive and behavioral measures. |
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| Keywords: | Fragile X syndrome EEG Power Resting-State Alpha Theta |
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