妊娠相关性乳腺癌的临床、病理及影像学特征

目的:探讨妊娠相关性乳腺癌(PABC)的临床、病理及影像学特征.方法:回顾性分析20例PABC患者的临床表现、病理分型及免疫组织化学结果、乳腺超声及MRI影像学特征.结果:20例患者的平均年龄为(32.45±3.41)岁(25～40岁),所有患者均可触及肿块,其中5例可触及腋窝淋巴结肿大.超声表现为形态不规则、边界欠清...

Pregnancy-associated breast cancer:A retrospective analysis with clinical,pathological and imaging features

Objective:To investigate the clinical,pathological and imaging features of pregnancy-associated breast cancer(PABC).Methods:The clinical manifestations,pathological typing,immunohistochemistry,breast ultrasound and MRI imaging characteristics of 20 patients with PABC were retrospectively analyzed.Results:The mean age of the patients was 32.45±3.41 years old,and ranged between 25 and 40 years old.All patients had palpable breast mass,and 5 patients had swollen and palpable axillary lymph nodes.Ultrasound showed irregular shape and unclear boundary of substantial mass,mostly low echo with/without strong echo light spot,and color doppler flow imaging(CDFI)showed blood flow signal.The lesions were mostly mass-like,with mixed signal intenstity on T₂WI and DWI(b=1000s/mm²)sequence of breast MRI.The average ADC value was(0.000719±0.000121)mm²/s.The dynamically enhanced TIC curves was mostly typeⅢ.Pathological results showed that invasive breast cancer accounted for 95%.The results of immunohistochemistry showed that ER-and PR-were the most common hormone receptors in patients.Conclusion:PABC patients were mostly diagnosed at a late stage with high malignancy.Ultrasound and MRI examination have important value in the detection of lesions,disease staging and differential diagnosis.Meanwhile,combined with pathological and immunohistochemical results,it can provide a beneficial basis for clinical development of personalized treatment plans.