MRI联合血清miR-204水平对原发性肝癌经皮穿刺射频消融术后疗效及复发的预测价值

目的:探讨MRI联合血清微小RNA(micro RNA,miR)-204水平对原发性肝癌射频消融(RFA)术后疗效及复发的预测价值.方法:选择2019年8月至2020年8月于本院行RFA治疗的原发性肝癌患者作为研究对象.于RFA术前一周内对研究对象行MRI检查,记录表观扩散系数(ADC)值;采用定量实时聚合酶联反应法测...

The predictive value of MRI combined with serum miR-204 level for the efficacy and recurrence of prima-ry liver cancer after percutaneous radiofrequency ablation

Objective:To investigate the predictive value of magnetic resonance imaging(MRI)combined with serum micro RNA(miR)-204 level for the efficacy and recurrence of primary liver cancer after percutaneous radiofrequency ablation(RFA).Methods:Patients with primary liver cancer who received RFA treatment in our hospital from August 2019 to August 2020 were selected as subjects.The Siemens Skyra 3.0T MR scanner was used to examine the subjects one week before RFA,and the apparent dispersion coefficient(ADC)was recorded and analyzed.Quantitative real-time polymerase linked reaction was used to determine the relative expression of miR-204 in serum.MRI was performed again one month after RFA to determine whether the lesion was ablated completely.Patients with complete ablation were followed up periodically for 1 years to record their recurrence status.Results:After RFA treatment,182(85.8%)patients were completely ablated,and 30(14.2%)patients remained after RFA treatment.There were no significant differences in gender,age,child-pugh grade,AFP before RFA,and associated diseases between the two groups(P>0.05).ADC in the complete ablation group was(1.30±0.12)×10^-3 mm²/s,which was significantly higher than that in the residual group(1.14±0.12)×10^-3 mm²/s(t=7.091,P<0.001).The relative expression level of serum miR-204 in the complete ablation group was(1.42±0.12),which was significantly higher than that in the residual group(1.25±0.10)(t=7.246,P<0.001).The AUC predicted by ADC,serum miR-204 and ADC combined serum miR-204 after RFA were 0.837(95%CI:0.750~0.923),0.860(95%CI:0.805~0.916)and 0.915(95%CI:0.861~0.970).The preoperative ADC of the recurrence group was(1.21±0.14)×10^-3 mm²/s,significantly lower than that of the non-recurrence group(1.33±0.13)×10^-3 mm²/s(T=5.052,P<0.001).The relative expression level of serum miR-204 in the recurrence group was(1.29±0.12),which was significantly lower than that in the non-recurrence group(1.46±0.14)(t=6.188,P<0.001).The AUC predicted by ADC,serum miR-204 and ADC combined serum miR-204 after RFA were 0.742(95%CI:0.646~0.838),0.822(95%CI:0.746~0.898)and 0.868(95%CI:0.807~0.929).Conclusion:MRI combined with serum miR-204 has certain predictive value for RFA postoperative efficacy and recurrence of primary liver cancer,which can provide reference for clinical application.