胃神经纤维瘤:1例报告及文献复习

目的探讨胃神经纤维瘤临床病理特点及鉴别诊断要点。方法对1例胃神经纤维瘤进行临床资料、组织形态学、免疫组化分析，并复习相关文献。结果本例为57岁女性，组织学特点：肿瘤由梭形细胞组成，波纹状排列，相互不规则交错，核分裂相未见。免疫组化显示：瘤细胞S-100蛋白弥漫阳性表达，不表达CK、SMA及DES，Alcian blue染色阳性。结论神经纤维瘤在胃肿瘤中罕见，其诊断主要依靠组织病理学和免疫组化标记。

Neurofibroma of the Stomach: Report of A Case and Review of the Literature

Purpose To study the clinicopathological characteristics and differential diagnosis of neurofibroma of the stomach. Methods The clinical,pathologic and immunohistochemical features of a case of neurofibroma of the stomach was studied with literatures reviewing. Results The case was a 57-year-old female.Histologica l characteristic,the tumor consisted of spindled cells in wavy arrangement,which interwove each other irregularly.And the nuclei of the cells showed no mitotic feature. Immunohistochemically,the tumor cells were strongly positive for S-100 protein,but negative for CK,SMA and DES.Also,the tumor cells were positive for Alcian blue stain. Conclusions Neurofibroma of stomach is especially rare. The dia-gnosis of the tumor is mainly depended on histopathology and immunohist ochemistry.