乳腺Paget's病的临床研究

目的探讨乳腺派杰氏病的临床与病理特点。方法对经手术和病理证实的乳腺派杰氏病10例，从临床表现与病理等方面加以分析。结果乳腺派杰氏病在乳腺癌中的发生率为0．8％，发病年龄39—60岁，平均49．7岁，病史1—120个月，乳头糜烂是最常见临床表现，治疗采取以手术为主的综合治疗，清扫腋窝淋巴结6—13枚，平均9枚，淋巴结转移1例（2／13枚）。结论乳腺派杰氏病作为特殊类型乳腺癌，发病率低，误诊率高，早期诊断和治疗可获得长期生存。

Paget's disease of the breast:clinical and pathological analysis of 10 cases

Objective To explore the clinical and pathological features,diagnosis,treatment and prognosis of Paget's disease.Methods From 1985 to 2006,10 patients with Paget's disease were operated and pathologically confirmed.Results Paget's disease accounted for 0.8% of the total morbility of the breast cancer. The range of age was 39-60 years,the mean age was 49.7years.The mean duration of the symptoms was 1-120 months.The most common symptom was anabrosis at nipple.All patients received combined treatment with surgery as the major modality .The mean number of lymph nodes obtained during operation were 9(6-13).Only 1 case got positive lymph nodes(2/13).Conclusion As a special type of breast cancer,Paget's disease has the features of low morbility,higher misdiagnosis and longer survival with early diagnosis and proper treatment.