A Case of Adult T-Cell Leukemia Initiated with Central Nervous System Symptoms |
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Authors: | AOYAGI, KUNIHIKO OKAMURA, SEIICHI SHIBUYA, TSUNEFUMI MATSUGUCHI, TETSUYA TSUDA, YASUO YAMANO, YUJIRO OTSUKA, TERUHISA UEDA, AKIRA NIHO, YOSHIYUKI |
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Affiliation: | *Department of Internal Medicine, Center for Adult Diseases Fukuoka The First Department of Internal Medicine, Faculty of Medicine, Kyushu University Fukuoka |
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Abstract: | We treated a 52-year-old Japanese woman with adult T-cell leukemia(ATL) initiated with central nervous system (CNS) symptoms.Her chief complaints were paraplegia and left facial palsy.CNS-ATL was diagnosed because of the following three features.1) Various sized lymphoid cells with marked nuclear convolutionwere numerous in her cerebrospinal fluid. 2) These cells werea monoclonal proliferation of T lymphocytes with OKT 4 marker.3) The patient's serum was positive for anti-ATL associatedantigen (ATLA). Although the neurological signs and symptomsimproved markedly after intrathecal administration of combinedchemotherapy (methotrexate, cytarabine and corti-costeroid),these ATL cells were highly resistant to radiation therapy.The abdominal mass which developed in the course of the diseasewas diagnosed as a tumor formed of ATL cells, and VEPA (vincristine,endoxan, prednisolone and adriamycin) was administered withmarked success. |
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Keywords: | Adult T-cell leukemia (ATL) Paraplegia Facial palsy CNS involvement |
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