| 监测48小时动态血压评估替米沙坦对轻、中度原发性高血压的疗效 |
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| 引用本文： | 李华,张博恒,初少莉,郭冀珍,诸骏仁.监测48小时动态血压评估替米沙坦对轻、中度原发性高血压的疗效[J].中国新药与临床杂志,2010(1). |
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| 作者姓名： | 李华 张博恒 初少莉 郭冀珍 诸骏仁 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院高血压科;复旦大学附属中山医院; |
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| 摘 要： | 目的观察替米沙坦48h血压控制的效果和对动脉硬化指数(AASI)的影响。方法轻、中度原发性高血压患者71例,经过2wk的清洗期后接受口服替米沙坦,80mg,qd,治疗8wk。治疗前接受24h动态血压监测,治疗8wk后接受48h动态血压监测,比较治疗前后血压以及AASI的变化。结果完成有效病例数60例。治疗8wk时,末次服药后d1的平均SBP和DBP分别为(134±s14)mmHg、(87±8)mmHg,末次服药后d2的平均SBP和DBP分别为(135±14)mmHg、(88±8)mmHg,均比治疗前(141±14)mmHg、(92±8)mmHg]显著下降(P<0.01);治疗的总有效率为60%(36/60),末次服药后d2有效率仍达50%(30/60)。对治疗有效的病例进行分析:SBP和DBP下降的平滑指数(SI)分别为1.02和0.89;清晨高血压患者的比例治疗前69%(25/36),治疗后下降至39%(14/36)(P<0.01),而所有患者夜间平均DBP均在60mmHg以上。治疗后AASI有下降趋势,但无显著差异(0.48±0.15vs.0.44±0.18,P>0.05),AASI的变化与脉压的改变密切相关。结论替米沙坦80mg能够持续48h控制轻、中度原发性高血压,降低清晨高血压,夜间血压无过度下降,对AASI的影响尚需进一步随访观察。
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| 关 键 词： | 替米沙坦 血压监测 便携式 高血压 治疗结果 |
Effects of telmisartan on mild to moderate essential hypertension assessed by 48 h ambulatory blood pressure monitoring |
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| LI Hua,ZHANG Bo-heng,CHU Shao-li,GUO Ji-zhen,ZHU Jun-ren.Effects of telmisartan on mild to moderate essential hypertension assessed by 48 h ambulatory blood pressure monitoring[J].Chinese Journal of New Drugs and Clinical Remedies,2010(1). |
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| Authors: | LI Hua ZHANG Bo-heng CHU Shao-li GUO Ji-zhen ZHU Jun-ren |
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| Institution: | LI Hua1,ZHANG Bo-heng2,CHU Shao-li1,GUO Ji-zhen1,ZHU Jun-ren2 (1.Department of Hypertension,Ruijin Hospital Affiliated to Shanghai Jiaotong University,SHANGHAI 200025,China,2.Zhongshan Hospital Affiliated to Fudan University,SHANGHAI 200032,China) |
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| Abstract: | AIM To observe the antihypertensive effect of telmisartan and its influence on ambulatory arterial stiffness index (AASI) in mild to moderate essential hypertension by 48 h ambulatory blood pressure monitoring (ABPM).METHODS After a 2-week wash out period,71 patients with mild to moderate essential hypertension received telmisartan 80 mg once daily for 8 weeks.Twenty-four h ABPM was performed before treatment,and 48 h ABPM was performed after the 8-week treatment.The change of blood pressure and AASI were a... |
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| Keywords: | telmisartan blood pressure monitoring ambulatory hypertension treatment outcome |
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