EFFECTS OF PANCURONIUM AND ALCURONIUM ON THE CHANGES IN ARTERIAL PRESSURE AND PLASMA CATECHOLAMINE CONCENTRATIONS DURING TRACHEAL INTUBATION |
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| Authors: | CUMMINGS, M. F. RUSSELL, W. J. FREWIN, D. B. |
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| Affiliation: | Department of Anaesthesia and Intensive Care Royal Adelaide Hospital, South Australia 5000
Department of Clinical Pharmacology Royal Adelaide Hospital, South Australia 5000 |
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| Abstract: | The changes in the plasma concentrations of noradrenaline, adrenalineand dopamine, during tracheal intubation, were studied in 17patients. Nine patients received pancuronium and eight alcuroniumto produce neuromuscular blockade. In the patients receivingpancuronium, intubation of the trachea was accompanied by anincrease in mean arterial pressure, and in the plasma concentrationsof noradrenaline and adrenaline. In the alcuronium group, therewere no significant changes in the plasma concentrations ofany catecholamine, nor any change in mean arterial pressurein response to intubation of the trachea. |
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