胃痛宁对胃溃疡大鼠胃组织表皮生长因子及一氧化氮含量的影响

目的 探讨胃痛宁治疗消化性溃疡的作用机理。方法 用冰醋酸制备大鼠慢性胃溃疡模型，观察胃痛宁治疗胃溃疡的愈合质量，再生黏膜厚度，溃疡瘢痕周围组织表皮生长因子(EGF)及一氧化氮(NO)含量。结果 胃痛宁组再生黏膜厚度，胃溃疡瘢痕周围组织EGF及NO含量均高于模型组(P<0．01，P<0．05)。结论 胃痛宁能提高溃疡愈合质量，提高溃疡瘢痕周围组织EGF及NO含量可能是胃痛宁抗消化性溃疡复发的机理之一。

Study on the Effect of Weitongning on Epidermal Growth Factor and Nitric Oxide Contents in Tissue of Stomach of Rats with Gastric Ulcer

ObjectiveTo study the therapeutic mechanism of Weitongning (WTN) in treating peptic ulcer. MethodsRat model of chronic gastric ulcer induced by galcial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer. ResultsThe thickness of regenerated mucous membrane, EGF and NO contents in peri ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0 01 or P<0 05). ConclusionWTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.