Ergometrine--a partial agonist at 5-HT receptors in the uterus isolated from the oestrogen-primed rat |
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| Authors: | M Hollingsworth D Edwards M Miller |
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| Affiliation: | Department of Physiological Sciences, Medical School, Manchester University, England. |
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| Abstract: | The mechanism of action of ergometrine has been studied in isolated uterus from the oestrogen-primed non-pregnant rat. Ergometrine (30 nM-1 microM) induced spasm and was antagonised selectively by methysergide and ICI 169,369, a proposed competitive antagonist at 5-hydroxytryptamine (5-HT2) receptors. The pA2 values of ICI 169,369 against 5-HT and ergometrine were not significantly different. Ergometrine (0.1-10 microM) was also a selective antagonist of 5-HT with no effect against acetylcholine or potassium chloride. It is suggested that ergometrine is a partial agonist involving 5-HT receptors in rat uterus. |
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