Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice |
| |
Authors: | Wormser Gary P Daniels Thomas J Bittker Susan Cooper Denise Wang Guiqing Pavia Charles S |
| |
Affiliation: | Department of Medicine, New York Medical College, Valhalla, NY 10595, USA. gary_wormser@nymc.edu |
| |
Abstract: | A prior study in mice has shown that the timely application of topical antibiotics to the skin at the tick bite site could eradicate Borrelia burgdorferi infection. That study, however, did not evaluate antibiotic preparations that are considered suitable for use in humans. In this murine study, topical application of 2% erythromycin and 3% tetracycline preparations that are acceptable for use in humans was found to be ineffective in eliminating B. burgdorferi from the tick bite site or in preventing dissemination to other tissues. Reasons for the discrepant findings are discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|