乙丙型肝炎病毒双重感染的临床观察

总结丙型肝炎１０４例，其中乙、丙型肝炎病毒双重感染６３例，认为二者重叠感染是我国丙型肝炎病毒（ＨＣＶ）感染的主要模式．血源性传播为丙肝的主要传播途径。肝细胞的损害程度受两种病毒复制活跃程度的影响，抗ＨＢｃ—ＩｇＭ阳性组，乙型肝炎病毒（ＨＢＶ）复制活跃，肝细胞损害重，预后差；并发ＨＣＶ感染后可加重肝细胞损害，慢转率增高。ＨＣＶ感染后对ＨＢＶ复制有一定抑制作用。

CLINICAL OBSERVATION ON DOUBLE INFECTION OF HEPATITIS VIRUSES B AND C

One hundred and four cases of hepatitis C were reported, including 63 cases hepatitis B and C double infection. So, the later were the main pattern of the infection in hepatitis C. Most of the patients have received blood or blood product transfusion. The damage degree to the liver cells was related to the activity of the replication of the HBV and the HCV. In the anti-HBc IgM positive group, the liver cells of the patients were seriously damaged as the HBV reproducing rapidly, and the patients without favorable prognosis. The hepatitis B patients coinfected or superinfected with HCV further damaged the liver cells,tending to turn to chronic hepatitis. In the double infection group, the HCV can somewhat inhibit the replication of the HBV.