| 经鼻给药对鼻粘膜结构的影响 |
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| 引用本文： | 王静清,卜国铉. 经鼻给药对鼻粘膜结构的影响[J]. 中华耳鼻咽喉头颈外科杂志, 1999, 0(1) |
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| 作者姓名： | 王静清 卜国铉 |
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| 作者单位： | 广东省珠海市人民医院耳鼻咽喉科(王静清)，长春白求恩医科大学第三临床医院耳鼻咽喉科(卜国铉) |
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| 摘 要： | 目的研究药物经鼻吸收时对鼻粘膜结构的影响。方法使用硫酸庆大霉素及胰岛素给家兔滴鼻，在用药后３、５、７ｄ和２周及停药后的１周及２周取鼻粘膜进行光学显微镜和透射显微镜观察。结果用药后３～７ｄ出现渐进性鼻粘膜损伤的改变，１周后部分区域上皮脱落，但基底膜完整。停药后１～２周内上皮细胞及纤毛迅速修复。结论鼻内给药是一种可行的有前途的给药途径。
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| 关 键 词： | 鼻粘膜 药物 吸收 |
Influence of intranasal medication on the structure of the nasal mucosa |
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| WANG Jingqing ,BU Guoxuan. De partment of Otorhinolaryngology,Zhuhai Municipal Hospital,Zhuhai. Influence of intranasal medication on the structure of the nasal mucosa[J]. Chinese journal of otorhinolaryngology head and neck surgery, 1999, 0(1) |
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| Authors: | WANG Jingqing BU Guoxuan. De partment of Otorhinolaryngology Zhuhai Municipal Hospital Zhuhai |
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| Affiliation: | WANG Jingqing *,BU Guoxuan. *De partment of Otorhinolaryngology,Zhuhai Municipal Hospital,Zhuhai 519000 |
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| Abstract: | Objective To study the pathological changes and reversibility of the nasal mucosa after drug administration. Methods Gentamicin and insulin were dropped into the nasal cavity of rabbits for 3,5,7 days to two weeks, after one and two weeks, the nasal mucosa was taken and observed under optical and electron microscopes. Results It was found that after 3 7 days of drugs administration, damages of the nasal mucosa gradually appeared, and became most serious after one week when the epithelia in some regions detached from basement membr theane. After stopping drug application, the ciliated epithelia restored quickly and completely, goblet cells reproduced and inflammatory reaction disappeared. Conclusion The damages induced by drugs on nasal mucosa are reversible. The intranasal route of drug administration is feasible and promising. |
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| Keywords: | Nasal mucosa Drugs Absorption |
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