急性缺血性脑卒中患者尿酸和高敏C反应蛋白检测的临床意义

目的 探讨急性缺血性脑卒中(AIS)患者血清中尿酸(UA)和高敏C反应蛋白(hs-CRP)水平变化的临床意义.方法 AIS患者223例,其中大面积脑梗死组49例,非大面积脑梗死组174例,对照组240例,分别测定其UA和hs-CRP水平,并进行比较分析.结果 AIS患者血清UA和hs-CRP水平较对照组均升高(P＜0.05)；大面积脑梗死组UA和hs-CRP水平较非大面积脑梗死组和对照组明显升高(P＜0.05)；非大面积脑梗死组较对照组UA(P＞0.05)和hs-CRP(P＜ 0.05)水平有所升高.结论 血清UA和hs-CRP与AIS的发生有关,且hs-CRP水平能反映脑梗死的病变程度.

Clinical Significance of Uric Acid and High-Sensitivity C-Reactive Protein Determination in Patients with Acute Ischemic Stroke

ObjectiveTo explore the clinical significance of serum uric acid(UA) and high-sensitivity C-reactive protein(hs-CRP) in patients with acute ischemic stroke(AIS).MethodsTotal 223 cases of AIS were divided into 49 cases with large cerebral infarction and 174 cases with non-large cerebral infarction.240 cases were vecruited as the normal control group.The UA and hs-CRP level were detected and the results were analyzed statistically.ResultsThe UA and hs-CRP in AIS group were higher than those in the control group and the differences had statistical significance(P<0.05).Large cerebral infarction group was compared with non-large cerebral infarction group and normal control group,and the differences had statistical significance(P<0.05).Non-large cerebral infarction group was compared with normal control group,and the difference of UA had no statistical significance(P>0.05).The difference of hs-CRP had statistical significance(P<0.05).ConclusionThe UA and hs-CRP level are related with AIS and the hs-CRP level can reflect the degree of cerebral infarction.