In Vitro Studies of Cefamandole |
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| Authors: | Gerald P. Bodey and Susanne Weaver |
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| Affiliation: | Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025 |
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| Abstract: | Cefamandole is a new cephalosporin antibiotic that was tested in vitro against 540 clinical isolates of gram-positive cocci and gram-negative bacilli. A concentration of 0.39 μg/ml inhibited 95% of the isolates of Staphylococcus aureus. A concentration of 6.25 μg/ml inhibited over 90% of the isolates of Proteus mirabilis and Escherichia coli, 69% of the isolates of Klebsiella pneumoniae, and 31% of the isolates of indole-positive Proteus spp. and Enterobacter spp. It was active against most cephalothin-resistant isolates of E. coli but not of K. pneumoniae. |
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