Reversible Posterior Leukoencephalopathy Syndrome Associated with Concurrent Bevacizumab,Gemcitabine, and Oxaliplatin for Cholangiocarcinoma

Introduction  

Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare disorder characterized by altered mental status, seizure, hypertension, and symmetrical white matter edema (leukoencephalopathy) typically in the posterior cerebral hemispheres on brain imaging. It is often linked to certain medication use, in particular, chemotherapeutic agents. Here, we present a case of chemotherapy-related RPLS and review the current literature on this topic.