炎症及冠脉病变形态与斑块稳定性的关系

目的:探讨冠状动脉斑块形态、炎症与斑块稳定性间的关系。方法:分析316例冠心病(CHD)患者冠脉造影(CAG)资料,根据斑块形态分为无病变组、Ⅰ型病变组、Ⅱ型病变组和Ⅲ型病变组。分别测定血清白细胞介素-6(IL-6)和高敏C反-应蛋白(hs-CRP)水平,分析比较不同斑块形态组间IL-6和hs-CRP水平,及CHD临床分型与斑块形态间的关系。结果:Ⅱ型病变组血清IL-6和hs-CRP水平明显高于Ⅰ型和Ⅲ型病变组(P<0.001);急性冠脉综合征(ACS)组Ⅱ型病变率明显高于稳定型心绞痛(SA)组。结论:不稳定型斑块患者体内炎症反应较稳定型斑块患者重,炎症的严重程度及斑块的形态影响冠脉斑块的稳定性。

Association between serum interleukin-6 and high sensitive C reactive protein levels and characteristics of coronary lesions

Objective: Association among inflammation,angiographic morphology and stability of coronary lesions were explored in this study.Methods:The data of coronary arteriongraphy were analyzed in 316 patients with coronary heart disease(CHD).The patients were assigned to no lesion group,type Ⅰ group,type Ⅱ group and type Ⅲ group according to angiographic morphology.The serum interleukin-6(IL-6)and high sensitive C reactive protein(hs-CRP)levels were measured in all objects.The serum IL-6 and hs-CRP levels were compared between different angiographic morphology groups and the association between angiographic morphology and gensini scoring of coronary lesions and clinical types of CHD were analyzed.Results:The serum IL-6 and hs-CRP levels were significantly higher in type Ⅱ group than that in type Ⅰ and Ⅲ group.The type Ⅱ lesion is more frequently occurred in acute coronary syndrome group than in stable angina group.Conclusion:Inflammatory reaction is more severe in patients with unstable lesions than patients with stable lesions.and the severity of inflammation and the morphology of lesion influence stability of coronary lesions.