| 凋亡抑制蛋白Survivin在肝癌中的表达和意义 |
| |
| 引用本文： | 朱虹,罗顺峰,张万广,张必翔,陈孝平. 凋亡抑制蛋白Survivin在肝癌中的表达和意义[J]. 肝胆外科杂志, 2002, 10(3): 232-233 |
| |
| 作者姓名： | 朱虹 罗顺峰 张万广 张必翔 陈孝平 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院肝脏外科中心,武汉,430030 |
| |
| 摘 要： | 目的 检测肝细胞癌中凋亡抑制蛋白Survivin的表达，并探讨其在肝细胞癌发生发展中的作用。方法 采用免疫组织化学技术和蛋白印迹技术，研究38例肝癌标本和10例肝硬化标本中Survivin蛋白的表达。结果 38例肝癌标本中23例表达Survivin蛋白，其中16例高，中分化肝癌，9例表达Survivin,22例低分化肝癌组织14例表达Survivin蛋白，而在癌周非癌组织和肝硬化组织中未检测到Survivin的表达。结论 Survivin在肝癌中高度表达可能与肝癌的发生发展有关，与预后的关系有待进一步的研究。
|
| 关 键 词： | Survivin 肝癌 肝硬化 |
| 文章编号： | 1006-4761(2002)03-0232-02 |
| 修稿时间： | 2002-02-21 |
EXPRESSION AND IMPLICATION OF INHIBITOR APOPTOSIS PROTEIN OF SURVIVIN IN HEPATOCELLULAR CARCINOMA |
| |
| Zhu Hong,Luo Shunfeng,Zhang Wanguang,Zhang Bixiang,Chen Xiaoping. EXPRESSION AND IMPLICATION OF INHIBITOR APOPTOSIS PROTEIN OF SURVIVIN IN HEPATOCELLULAR CARCINOMA[J]. Journal of Hepatobiliary Surgery, 2002, 10(3): 232-233 |
| |
| Authors: | Zhu Hong Luo Shunfeng Zhang Wanguang Zhang Bixiang Chen Xiaoping |
| |
| Affiliation: | Zhu Hong,Luo Shunfeng,Zhang Wanguang,Zhang Bixiang,Chen Xiaoping.Center of Hepatic Surgery,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430030,China |
| |
| Abstract: | Objective To investigate the expression of inhibitor apoptosis protein of survivin,and determine the role in hepatocellular carcinoma(HCC).Methods The expression of survivin was detected by immunhischemistry and Western blot.38 cases HCC and 10 cases cirrhosis specimen were examined.Results 23 cases of HCC express survivin.9 out of 16 cases of middle to well differentiated HCC were detected survivin expression,14 out of 22 cases with poorly differentiated HCC were found survivin expression.Survivin was not detected in non cancerous adjacent liver tissues and cirrhosis tissue.Conclusion A high expression of survivin in HCC suggests that it play an important role in the origin and development of HCC,but the relationship with prognosis is not still clear. |
| |
| Keywords: | Survivin Hepatocellular carcinoma Cirrhosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
