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Increased mortality in HIV/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death
Authors:Mathieu Chalouni  Stanislas Pol  Philippe Sogni  Hélène Fontaine  Karine Lacombe  Jean Marc-Lacombe  Laure Esterle  Celine Dorival  Marc Bourlière  Firouzé Bani-Sadr  Victor de Ledinghen  David Zucman  Dominique Larrey  Dominique Salmon  Fabrice Carrat  Linda Wittkop
Affiliation:1. ISPED, INSERM, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, University of Bordeaux, Bordeaux, France;2. Assistance Publique – Hôpitaux de Paris, Hôpital Cochin, Département d''Hépatologie, Université de Paris, INSERM U-1223 et ICD, Institut Pasteur, Paris, France;3. INSERM, Institut Pierre Louis d''Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, Paris, France;4. APHP, Hôpital Saint-Antoine, Service de Maladies Infectieuses et Tropicales, Paris, France;5. INSERM Transfert, Paris, France;6. Department of Hepatology and Gastroenterology, Hôpital Saint Joseph, Marseille, France;7. Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims, France;8. Service d''Hépatologie, Centre Hospitalier Universitaire de Bordeaux, Hôpital Haut-Lévêque, Bordeaux, France;9. INSERM U1053, Université de Bordeaux, Bordeaux, France;10. Service de Médecine Interne, Hôpital Foch, Suresnes, France;11. Service des Maladies de l''Appareil Digestif, Hôpital Saint Eloi, IBR – INSERM, Montpellier, France;12. Université de Paris, Paris, France;13. Service Maladies Infectieuses et Tropicales, AP-HP, Hôpital Cochin Hôtel Dieu, Paris, France;14. AP-HP, Hôpital Saint-Antoine, Unité de Santé Publique, Paris, France;15. CHU de Bordeaux, Pôle de Santé Publique, Bordeaux, France;1. Department of Gastroenterology and Hepatology, Kantonsspital, St. Gallen, Switzerland;2. Center for Medical Oncology & Hematology, Spital STS Thun, Switzerland;3. Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland;4. Clinical Trials Unit, Kantonsspital, St. Gallen, Switzerland;5. Institute of Radiology and Nuclear Medicine, Kantonsspital, St. Gallen, Switzerland;1. Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;2. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia;3. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;4. Institute of Liver Studies, Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Liver Sciences and Medicine, King''s College London, London, UK;5. Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;1. Department of Organ Transplant, Scripps Clinic, La Jolla, CA;2. Inland Empire Liver Foundation, Rialto, CA;3. California Liver Research Institute, Pasadena, CA;4. Methodist Health System Clinical Research Institute, Dallas, TX;5. Diabetes & Endocrinology Consultants, PC, Moorhead City, NC;6. Covenant Research, Lakewood Ranch, FL;7. IMIC Inc, Palmetto Bay, FL;8. Mercy Medical Center, Baltimore, MD;9. University of Pennsylvania Medical Center, Philadelphia, PA;10. Delta Research Partners, Bastrop, LA;11. Conatus Pharmaceuticals, Inc., San Diego, CA;12. SimulStat, Inc., Solana Beach, CA;13. Liver Institute Northwest, Seattle, WA;1. Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA;2. Microbiome Analysis Center, George Mason University, Manassas, VA, USA;3. Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
Abstract:
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  • Keywords:HIV coinfection  DAA treatment  SVR  Death  Non-liver-related cancers  Liver-related events
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