Role of the HLA-G immune checkpoint molecule in pregnancy |
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Authors: | Nathalie Rouas-Freiss Philippe Moreau Joel LeMaoult Bela Papp Diana Tronik-Le Roux Edgardo D Carosella |
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Institution: | 1. CEA, DRF-Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France;2. U976 HIPI Unit, IRSL, Université Paris, Paris, France |
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Abstract: | The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of trophoblast invasion, uterine vascular remodeling, and maintenance of a local immunosuppressive state. Understanding HLA-G biology at the maternal-fetal interface is therefore a critical issue in reproduction. In this regard, we review here: (i) the effects of HLA-G on decidual leucocytes and stromal cells, (ii) the contribution of trogocytosis in HLA-G expression on decidual cells, (iii) its interaction with the ILT2, ILT4 and KIR2DL4 receptors, (iv) the link between HLA-G polymorphism and pregnancy disorders, and (v) the expression of newly-described HLA-G isoforms at the maternal-fetal interface. |
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Keywords: | HLA-G Polymorphism Isoform Trogocytosis Signaling |
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