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CD40-mediated immune cell activation enhances response to anti-PD-1 in murine intrahepatic cholangiocarcinoma
Authors:Laurence P Diggs  Benjamin Ruf  Chi Ma  Bernd Heinrich  Linda Cui  Qianfei Zhang  John C McVey  Simon Wabitsch  Sophia Heinrich  Umberto Rosato  Walter Lai  Varun Subramanyam  Thomas Longerich  Sven H Loosen  Tom Luedde  Ulf Peter Neumann  Sabina Desar  David Kleiner  Tim F Greten
Institution:1. Thoracic & GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;2. Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;3. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;4. Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany;5. Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Germany;6. Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen Aachen, Germany;7. Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland, USA;8. Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA;9. NCI CCR Liver Cancer Program, National Institutes of Health, Bethesda, Maryland 20892, USA;1. Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Denmark;2. Division of Cancer Epidemiology and Genetics, NIH, Rockville, MD, USA;3. Cancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA;4. Statistical Genetics Research Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany;5. The CGR Exome Studies Group, NIH, Rockville, MD, USA;6. Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;7. Advanced Center for Chronic Diseases (ACCDiS), FONDAP, Santiago, Chile;8. Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;9. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;10. Stanford Cancer Institute and Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford, CA, USA;11. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China;12. Hospital Dr. Hernán Henríquez Aravena, Temuco, Chile;13. Department of Pathology, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile;1. Unit of Oncogenomics and Epigenetics, IRCCS Regina Elena National Cancer Institute, Rome, Italy;2. Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy;3. SAFU, IRCCS Regina Elena National Cancer Institute, Rome, Italy;4. UOSD Clinical Trial Center, Biostatistics and Bioinformatics, IRCCS Regina Elena National Cancer Institute, Rome, Italy;5. Istituto Dermopatico dell''Immacolata, IDI-IRCCS, Rome, Italy;6. Division of Hematology and Oncology, Mayo Clinic, Scottsdale, USA;7. Division of Hepatobiliary Pancreatic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy;8. Department of Oncology, University of Torino, Candiolo, Italy;9. Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy;10. Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;1. School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China;2. Department of Liver Surgery, Liver Transplantation Division, West China Hospital, Sichuan University, Chengdu, China;3. Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, United States;4. Institute of Pathology, University of Greifswald, Greifswald, Germany;5. Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China;6. Institute of Pathology, University of Regensburg, Regensburg, Germany;7. Department of General Surgery, The Second Hospital of Xi''an Jiaotong University, Xi''an Jiaotong University, Xi''an, China;8. Department of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China;9. Unit of Pathology, Azienda Ospedaliero Universitaria Sassari, Sassari, Italy;10. Department of Medicine, University of California, San Francisco, CA, United States;11. Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China;1. Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;2. Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;3. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China;4. Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China;5. Department of Gastroenterology, Guizhou Provincial People''s Hospital, Guizhou, China;6. Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China;7. Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA;8. School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, China;9. Department of Pediatrics and Institute for Computational Health Sciences, University of California, San Francisco, CA, USA;10. Department of Gastroenterology, 307 Hospital of PLA, Beijing, China;11. Institute of Pathology, University of Greifswald, Greifswald, Germany;12. Institute of Pathology, University of Regensburg, Regensburg, Germany;13. Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy;14. Unit of Pathology, Azienda Ospedaliero Universitaria Sassari, Sassari, Italy;15. National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, Italy;16. Department of Medicine, University of California, San Francisco, CA, USA;1. University of Navarra, Centre for Applied Medical Research, Program in Solid Tumours, Pamplona, Spain;2. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;3. University of Navarra, Centre for Applied Medical Research, Computational Biology Program, Pamplona, Spain;4. ProteoRed-Instituto de Salud Carlos III (ISCIII), Madrid, Spain;5. University of the Basque Country, San Sebastian, Spain;6. Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute – Donostia University Hospital –, University of the Basque Country (UPV/EHU), San Sebastian, Spain;7. National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Instituto de Salud Carlos III), Spain;8. Institute of Pathology, University of Regensburg, Regensburg, Germany;9. University of Rochester Medical Centre, Rochester, NY, USA;10. Cancer Signalling Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Pamplona, Spain;11. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC, Instituto de Salud Carlos III), Madrid, Spain;12. University of Navarra, Department of Pathology, Anatomy and Physiology, Pamplona, Spain;13. University of Navarra, Centre for Applied Medical Research, Hepatology Program, Pamplona, Spain;14. Clinica Universidad de Navarra, Department of Medical Oncology, Pamplona, Spain;15. Ikerbasque, Basque Foundation for Sciences, Bilbao, Spain;1. Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Abstract:
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  • Keywords:Cholangiocarcinoma  Liver cancer  Tumor-infiltrating lymphocyte  T cell  NK cell  Antigen-presenting cell  Macrophage  Dendritic cell  Immunotherapy  Immune checkpoint  CD40 agonist
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