Plasma cerebellin levels in patients with central serous chorioretinopathy |
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| Authors: | S. Gungor Kobat E. Yusufoglu F.C. Gul F. Celik M. Kalayci |
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| Affiliation: | 1. Elaz?g Health Science University, Department of Ophthalmology, Elaz?g, Turkey;2. Elaz?g Health Science University, Department of Biochemistry, Elaz?g, Turkey;1. CHNO des Quinze-Vingts, IHU Foresight, Inserm-DGOS CIC 1423, 28, rue de Charenton, 75012 Paris, France;2. Sorbonne Université, Inserm, CNRS, Institut de la Vision, 17, rue Moreau, 75012 Paris, France;3. Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, University of Versailles Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France;1. Centre hospitalier national d’ophtalmologie des Quinze-Vingts, IHU de Foresight, Inserm-DGOS CIC 1423, 28, rue de Charenton, 75012 Paris, France;2. Inserm, Sorbonne université, CNRS, institut de la Vision, 17, rue Moreau, 75012 Paris, France;3. Service d’ophtalmologie, hôpital Ambroise-Paré, AP–HP, université de Versailles Saint-Quentin-en-Yvelines, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France |
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| Abstract: | PurposeTo evaluate levels of plasma cerebellin, cortisol, adrenaline and noradrenaline in patients with central serous chorioretinopathy (CSC).Materials and MethodsThis prospective study included 30 patients diagnosed with acute CSC (Group 1) and a control group of 30 age-matched, healthy subjects without CSC (Group 2). Levels of plasma cerebellin, cortisol, adrenaline and noradrenaline were examined in blood samples taken after 8-12 hours of fasting. A value of p < 0.05 was considered statistically significant in the comparative analyses.ResultsThe mean plasma cerebellin level was found to be 232.56 ± 113.28 pg/ml in Group 1 and 174.07 ± 82.04 pg/ml in Group 2 (p = 0.02). Mean plasma cortisol was 13.19 ± 3.87 μg/ml in Group 1 and 9.55 ± 2.92 μg/ml in Group 2 (p < 0.01). Mean plasma adrenaline was 60.62 ± 26.67 pg/ml in Group 1 and 46.17 ± 19.20 pg/ml in Group 2 (p = 0.03). Mean plasma noradrenaline was 206.66 ± 73.90 pg/ml in Group 1 and 149.96 ± 51.36 pg/ml in Group 2 (p < 0.01).ConclusionIt can be concluded that increased cerebellin may have a role in the etiology of CSC by increasing catecholamine expression from the adrenal medulla and indirectly by increasing cortisol levels via a paracrine effect from the adrenal cortex. |
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| Keywords: | Central serous chorioretinopathy cerebellin cortisol adrenaline noradrenaline Choriorétinopathie séreuse centrale cérébelline cortisol adrénaline noradrénaline |
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