NGS-based typings for 7 HLA loci in three populations from Rio de Janeiro,RJ, Brazil |
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| Authors: | Romulo Vianna Leonardo Hanhoerderster Juliana Cardoso Luís Cristóvão Porto |
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| Institution: | Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Avenida Marechal Rondon 381, 20950-003 Rio de Janeiro, Brazil |
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| Abstract: | We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 759 Brazilian individuals from three populations in the Rio de Janeiro city based on their self-declared skin color (Caucasian, N = 521, AFND-ID: 3730; Parda, N = 170, AFND-ID: 3728; Black, N = 68, AFND-ID: 3727) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. Only HLA-DRB1 locus deviated from Hardy-Weinberg equilibrium (in Caucasian and Black populations). The three populations shared the most frequent allele on HLA-A, -C, -DRB1, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database. |
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| Keywords: | HLA Next-generation sequencing Population immunogenetics Rio de Janeiro Brazil |
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