Identification of genetic biomarkers in urine for early detection of prostate cancer |
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| Authors: | Eyyup Kavalci Ali Ulvi Onder Klaus Brusgaard Aysegul Bostanci Mehmet Yavuz Selhanoglu Nedime Serakinci |
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| Affiliation: | 1. Department of Medical Biology and Genetics, Near East University, Graduate School of Health Sciences, Nicosia, North Cyprus, Mersin 10, Turkey;2. Department of Urology, Faculty of Medicine, Near East University, Nicosia, North Cyprus, Mersin 10, Turkey;3. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense C, Denmark;4. Department of Medical Microbiology and Clinical Microbiology, Near East University, Graduate School of Health Sciences, Nicosia, North Cyprus, Mersin 10, Turkey;5. Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, North Cyprus, Mersin 10, Turkey;6. Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Near East University, Nicosia, North Cyprus, Mersin 10, Turkey |
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| Abstract: | Prostate cancer screening is a challenging and vital issue in the aspects of the current tests and risk assessments. Prostate cancer risk assessments are currently carried out by using blood, urine and tissue biomarkers with radiological imaging methods. Here, we introduce a novel noninvasive screening tool for a further in-depth selection of eligible cases for prostate biopsies which is based on sequencing somatic and hereditary HOXB13 mutations in urine samples. This approach provides diagnostic information to the physician about the presence of prostate cancer while aiming to screen for specific prostate biopsies and save biopsies potentially when there are no mutations related to prostate cancer. Findings suggest that this method is reliable, cost-effective, and has a promising potential in prostate cancer screening. |
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