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Risk of Systemic Adverse Events after Intravitreal Bevacizumab,Ranibizumab, and Aflibercept in Routine Clinical Practice

Authors:	Maya H Maloney Stephanie R Payne Jeph Herrin Lindsey R Sangaralingham Nilay D Shah Andrew J Barkmeier

Institution:	1. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota;2. Department of Ophthalmology, Kaiser Permanente, Vacaville, California;3. Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;4. Yale School of Medicine, Yale University, New Haven, Connecticut;5. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota;6. Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota;7. OptumLabs, Cambridge, Massachusetts

Abstract:

Keywords:	anti-VEGF aflibercept ranibizumab bevacizumab age-related macular degeneration diabetic retinopathy retinal vein occlusion CI"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"confidence interval CVD"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"cerebrovascular disease DME"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"diabetic macular edema DRD"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"diabetic retinal disease FDA"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"Food and Drug Administration HR"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"hazard ratio ICD-9"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"International Classification of Diseases 9th Revision ICD-10"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"International Classification of Diseases 10th Revision IQR"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"interquartile range MI"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"myocardial infarction nAMD"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"neovascular age-related macular degeneration RVO"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"retinal vein occlusion SAE"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"systemic adverse event VEGF"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"vascular endothelial growth factor
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