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Societal awareness on neonatal hyperbilirubinemia: A systematic review and meta-analysis
Authors:Zubaida L Farouk  Fatima Usman  Baba Maiyaki Musa  Veronica Chinyere Ezeaka  Angela Okolo
Institution:1. Department of Paediatrics, Bayero University, Kano Nigeria;2. Department of Medicine, Bayero University, Kano Nigeria;3. Department of Pediatrics, Lagos University Teaching Hospital, Nigeria;4. Department of Paediatrics, UBTH Nigeria;1. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA;2. Division of Newborn Medicine, Harvard Medical School, Boston, Massachusetts, USA;3. Division of Neonatology, University of Florida, Gainesville, Florida, USA;4. Division of Neonatology, Oregon Health and Science University, Portland, Oregon, USA;5. Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York, USA;6. Division of Newborn Medicine, Boston Children''s Hospital, Boston, Massachusetts, USA;7. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA;1. Fetal and Neonatal Medicine Institute, Division of Neonatal Medicine, Children''s Hospital Los Angeles; Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, MS #31, Los Angeles, CA 90027, United States;2. Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, United States;3. Division of Neonatology, Department of Pediatrics, Oregon Health Sciences University, Portland, OR, United States;1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA;2. Division of Newborn Medicine, Texas Children''s Hospital, Houston, TX, USA;3. Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, USA;4. Division of Newborn Medicine, Harvard Medical School, Boston, MA, USA;5. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA;1. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA;2. Department of Neonatology, Harvard Medical School, Boston, MA;1. Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan;2. Kobe University Graduate School of Medicine, Kobe, Japan
Abstract:Early recognition of neonatal hyperbilirubinemia is essential for prevention of bilirubin neurotoxicity and its long-term sequelae. High rates of home delivery in low- and middle-income countries (LMICs) as well as early discharge post-delivery (within 24hours) make community surveillance for neonatal hyperbilirubinemia highly important. Here, we performed a literature review to estimate the level of societal awareness of neonatal hyperbilirubinemia. We searched several databases for studies assessing the knowledge and awareness of neonatal hyperbilirubinemia. We retrieved 211 citations from 206 databases with five being in the grey literature. 52 selected articles were further reviewed. Data from these studies were then analyzed using Stata software (Statacorp® LLC Texas USA). We found that the pooled estimate of societal awareness of neonatal hyperbilirubinemia was 67% (95% confidence interval CI]: 60, 74). There however was a publication bias (Begg test: P ≤ 0.01; Egger P = 0.06). Studies that scored or graded knowledge reported lower estimates adjusted odds ratio (aOR) = -0.17; 95% CI: -0.32–0.02; P = 0.03]. Hospital location was an important determinant of awareness of complications aOR = 0.30; 95% CI: 0.30–0.57; P = 0.03]. We therefore concluded that there is a significant need to improve societal awareness of neonatal hyperbilirubinemia.
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