| 氟哌啶醇季铵盐衍生物抗实验性心律失常的作用 |
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| 引用本文： | 黄展勤,石刚刚,刘幸平,高分飞,李长潮. 氟哌啶醇季铵盐衍生物抗实验性心律失常的作用[J]. 汕头大学医学院学报, 2006, 19(2): 67-69 |
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| 作者姓名： | 黄展勤 石刚刚 刘幸平 高分飞 李长潮 |
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| 作者单位： | 汕头大学医学院药物研究室,广东,汕头,515041 |
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| 基金项目： | 国家自然科学基金;国家新药研究项目;广东省自然科学基金 |
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| 摘 要： | 目的：研究氟哌啶醇季铵盐衍生物（F2）抗实验性大鼠心律失常的作用。方法：采用氯化钡（BaCl2）诱导的心律失常大鼠模型，观察F2对实验性心律失常的预防作用。结果：静注F2（2mg／kg）、利多卡因（2mg/kg）及维拉帕米（2mg/kg）均可减少大鼠心律失常发生率，降低死亡率并缩短心律失常的持续时间。结论：F2对BaCl2诱导的大鼠心律失常有较好的预防作用。
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| 关 键 词： | 氟哌啶醇 心律失常 氯化钡 |
| 文章编号： | 1007-4716（2006）02-0067-03 |
| 收稿时间： | 2006-04-06 |
| 修稿时间： | 2006-04-06 |
Effects of Quaternary Ammonium Salt Derivative of Haloperidol on Experimental Arrhythmia |
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| HUANG Zhan-qin,SHI Gang-gang,LIU Xing-ping,GAO Fen-fei,LI Chang-chao. Effects of Quaternary Ammonium Salt Derivative of Haloperidol on Experimental Arrhythmia[J]. Journal of Shantou University Medical College, 2006, 19(2): 67-69 |
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| Authors: | HUANG Zhan-qin SHI Gang-gang LIU Xing-ping GAO Fen-fei LI Chang-chao |
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| Affiliation: | Department of Pharmacology, Shantou University Medical College, Shantou 515041, China |
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| Abstract: | Objective:To study the effects of quaternary ammonium salt derivative of haloperidol(F-2)on experimental arrhythmia induced by barium chloride(BaCl-2).Methods:The arrhythmic models induced by BaCl-2 in rats were used to observe the preventive effects of F-2 on experimental arrhythmia.Results:F-2(2 mg/kg)could decrease the incidence rate and mortality rate of arrhythmia,and shorten the duration of arrhythmias induced by BaCl-2.Conclusion:F-2 has significant effects on BaCl-2-induced arrhythmia in rats. |
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| Keywords: | haloperidol arrhythmia barium chloride |
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