不稳定型心绞痛患者血浆纤维蛋白原和C-反应蛋白含量的变化

目的:探讨血浆纤维蛋白原含量(Fib)在不稳定型心绞痛(UAP)发展过程中的变化。方法:65例患者分为3组:UAP组(n=23)、稳定型心绞痛(SAP)组(n=22)和对照组(n=20)。UAP组又分为有并发症组(n=17)和无并发症组(n=6)两个亚组。入院时取静脉血检查血糖、血脂、血浆Fib水平和肝、肾功能、C反应蛋白(CRP)等。UAP组48h后重复检测Fib和CRP。结果:UAP组CRP、Fib血浆水平明显高于对照组(P<0.01);SAP组CRP、Fib血浆水平与对照组相比差异有显著性(P<0.05);入院时,有并发症组血浆Fib和CRP水平高于无并发症组(P<0.01);48h后,有并发症组的Fib、CRP血浆水平较入院时高(P<0.05),而无并发症组较入院时差异无显著性(P>0.05)。结论:48h前后血浆Fib和CRP水平的变化,可能反映了疾病的活动程度和预后。

Changes of Plasma Fibrinogen and C reaction protein in Patients with Unstable Angina Pectoris

Objective: To assess the role of plasma fibrinogen in patients with unstable angina pectoris.Method: 65 patients were divided into 3 groups: Unstable angina Pectoris(UAP n=23),Stable angina pectoris(SAP n=22)and Control group(n=20).UAP group was divided into 2 groups: group1 consisted of 17 patients with complications,and group 2 consisted of 6 patients without complications.For each patient,plasma levels of fibrinogen,C reaction protein(CRP), glucose,lipid and liver function,kidncy function were measured at entry a hospital.UAP group was measured 48 hours after admission.Results: (1) The mean plasma FIB and CRP were significantly higher in UAP group than in control group.( P<0.01 ).(2)There were significant differences in the plasma FIB and CRP between the SAP and the control groups(P<0.05).(3)The plasma FIB and CRP in UAP group1 were higher than that in UAP group2(P<0.01).Furthermore,the plasma FIB and CRP reexamined 48 hours after admission of UAP group1 were higher than that of UAP group1 on admission(P<0.05).Conclusion: The change of plasma FIB and CRP 48 hours after admission was associated with a complicated hospital course.