行为生活方式等因素与脂肪肝患病关联性研究

[目的]探讨行为生活方式等因素与脂肪肝患病的关联性。[方法]采用病例对照研究方法,选择2006年4～9月期间在本院健康体检的292例经超声诊断为脂肪肝者为病例组,同期体检人群中性别、职业相同,年龄相差±2岁的292例非脂肪肝者为对照组。[结果]单因素分析结果表明,与脂肪肝患病显著相关的有肥胖与超重、高血糖、高TC血症、高TG血症、高尿酸血症、吸烟、饮食习惯、经常运动等8个变量,其中经常运动与脂肪肝患病呈负相关;其中与酒精性脂肪肝患病显著相关的有肥胖与超重、高血糖、高TC血症、高TG血症、高LDL-C血症、高尿酸血症、吸烟、饮食习惯等8个变量;与非酒精性脂肪肝患病显著相关的有肥胖与超重、高血糖、高TG血症、高HDL-C血症、经常运动等5个变量(高HDL-C血症、经常运动与非酒精性脂肪肝患病呈负相关)。多因素非条件Logistic回归分析结果表明,影响脂肪肝发生的独立因素为肥胖与超重、高血糖、高TG血症、高尿酸血症,尤以肥胖意义较大,OR值为14.746。其中酒精性脂肪肝发生的独立因素为肥胖与超重、高血糖、高TG血症、高LDL-C血症、高尿酸血症、吸烟、饮食习惯(高脂 嗜咸),尤以肥胖意义最大,OR值为17.498;非酒精性脂肪肝发生的独立因素为肥胖与超重、高TG血症、高HDL-C血症、经常运动,其中肥胖与超重、高TG血症的OR值﹥1,尤以肥胖意义较大,OR值为10.314,而高HDL-C血症、经常运动的OR值﹤1,分别为0.503、0.465。[结论]超重与肥胖、糖、酯代谢异常、饮洒、高脂 嗜咸饮食、吸烟是脂肪肝患病的危险因素,经常运动、血清HDL-C升高则对脂肪肝患病有显著的保护作用。

RESEARCH ON THE ASSOCIATION BETWEEN BEHAVIORS AND LIFE STYLE AND FATTY LIVER

[Objective] To study the association between behaviors and life style and fatty liver. [Methods] Case control study method was applied in this research. We chose 292 fatty liver patients, who took the physical examinations and were confirmed the disease with ultrasound in our hospital between April 2006 and September 2006, as the experiment group. Another 292 normal subjects with same sex, same career, the age difference within 2 years, who also took physical examinations at the same period, were selected as the control group. [Results] The result from the single factor analysis showed that eight factors significantly related to fatty liver were overweight with obesity, high plasma glucose, high TC, high TG, high uric acid, smoking, eating, and frequent exercise, where frequent exercise was negatively related to fatty liver. Among them, there were eight factors related to alcoholic fatty liver, which were overweight with obesity, high plasma glucose, high TC, high TG, high LDL-C, high uric acid, smoking and eating. Also, five factors related to non-alcoholic fatty liver were overweight with obesity, high plasma glucose, high TG, high HDL-C, and frequent exercise. (High HDL-C and frequent exercise were negatively re- lated to non-alcoholic fatty liver.) The result from multi-variable non-conditional logistic regression analysis showed that the independent factors causing fatty liver were overweight with obesity, high plasma glucose, high TG, high uric acid, in which obesity was the relatively more important factor with OR value 14.746. The independent factors related to alcoholic fatty liver were overweight with obesity, high plasma glucose, high TG, high LDL-C, high uric acid, smoking and eating (high fat plus high salt), where obesity was the most important factor with OR value 17.498. The independent factors for non-alcoholic fatty liver were overweight with obesity, high TG, high HDL-C, frequent exercise, where the OR values of first two factors were greater than 1, and obesity was more important with OR value 10.314. Also, the OR values of the last two factors were less than 1, and the value was 0.503 and 0.465, respectively. [Conclusion] The dangerous factors for fatty liver patients are overweight with obesity, glucose, ester metabolic irregularity, alcohol, eating with high fat and high salt, and smoking. On the other hand, frequent exercise and the increase of the HDL-C provide significant protection for fatty liver patients.