西酞普兰治疗老年抑郁症对照研究

目的：探讨西酞普兰治疗急性期老年抑郁症的有效性及安全性。方法：收集各类抑郁急性发作、年龄≥60岁的患者进行西酞普兰和阿米替林单盲对照治疗，治疗8周。疗效及安全性评定采用17项汉密顿抑郁量表和副反应量表。结果：70例完成观察，其中西酞普兰组34例，阿米替林组36例。治疗第2周时，西酞普兰组有效率显著较高。在第8周时两组疗效差异无显著性。西酞普兰组的不良反应明显较少。结论：西酞普兰见效较快，不良反应较少，适合于老年抑郁症特别是伴有躯体疾病患者的急性期治疗。

A comparative studv of citalopram and amitriptvline in elderly depressive patients

Objective:To study the efficacy and tolerability of citalopram in elderly with acute depression. Method:Patients at least 60 years old with major depression were eligible.They were randomized to receive citalopram or amitriptyline in sequence.Efficacy was assessed with the Hamilton rating scale for depression (HAMD) and tolerability was assessed from rating scale for adverse effect. Results:70 patients were studied,34 with citalopram and 36 with amitriptyline were included in the efficacy analysis.Differences favoring citalopram were observed for the mean change from baseline in HAMD-17 score at 2 weeks after the treatment,but without significant difference at 8 weeks after the treatment.The citalopram group also showed less adverse effects than the amitriptyline group. Conclusion:Citalopram had faster on effect,also demonstrated a better tolerability profile and represents a valuable option for the treatment of acute depression in elderly patients and especially suit to the patients with somatic diseases.