| 电针缓解吗啡戒断大鼠的心动过速 |
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| 引用本文： | 喻允国,崔彩莲,于吉人,韩济生.电针缓解吗啡戒断大鼠的心动过速[J].中国中西医结合杂志,2000,20(5):353-355. |
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| 作者姓名： | 喻允国 崔彩莲 于吉人 韩济生 |
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| 作者单位： | 1. 北京医科大学神经科学研究所,北京,100083
2. 北京医科大学生理系 |
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| 基金项目： | 国家自然科学基金资助(No.39570682) |
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| 摘 要： | 目的：建立吗啡戒断大鼠心动过速模型，观察不同频率电针对其心率的影响。方法：给大鼠连续注射递增量吗啡８天，造成其对吗啡依赖。停药后１８～２４ｈ给于强度为１ｍＡ，频率为２Ｈｚ、１５Ｈｚ、１００Ｈｚ的电针刺激，记录清醒状态下吗啡戒断大鼠的心率和血压。结果：与正常大鼠比较吗啡戒断大鼠心率显著增快（Ｐ〈０．０１），但平均动脉压无显著性差异。１５Ｈｚ和１００Ｈｚ电针对吗啡戒断大鼠的心动过速均有显著抑制作用（使
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| 关 键 词： | 电针 吗啡戒断 心动过速 平均动脉压 电针疗法 |
| 修稿时间： | 1999年1月4日 |
Tachycardia Ameliorated by Electroacupuncture in Morphine Withdrawal Rats |
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| Authors: | YU Yunguo CUI Cailian YU Jiren |
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| Affiliation: | Neuroscience Research Institute, Beijing Medical University, Beijing (100083). |
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| Abstract: | To establish morphine withdrawal tachycardia model of rat and to observe the effect of elec-troacupuncture (EA) with different frequency on its heart rate. Methods: Morphine dependence was induced inWistar rats by injection of morPhine for 8 days successively, and EA 1 rnA in strength was given after withdraw-alof morphine with different frequencies of 2 Hz, 15Hz and 100Hz, the heart rate and blood pressure wererecorded in the awaked rats. Result8: Morphine abstinent rats showed a 24% increase of heart rate as comparedwith that of the normal control group, but no significant change was observed in blood pressure. The lOOHz and15Hz EA produced a 13. 4% and 13. 1 % decrease of heart rate respectively, whereas 2Hz EA produced insignifi-cant change. Conclusion: The reducing effect of percutaneous electric stimulation on tachycardia in heroin ad-dicts revealed clinically can be replicated in the rat model. |
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| Keywords: | electroacupuncture morphine withdrawal rats heart rate tachycardia mean blood pressure |
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