美托洛尔抗高血压预防脑卒中的实验病理学研究

目的探讨抗高血压治疗预防脑卒中的形态学机制。方法采用易卒中型肾血管性高血压大鼠口服美托洛尔治疗，观察抗高血压治疗各级脑动脉和心室壁厚度的形态学改变。结果治疗组大鼠血压仅短期轻度低于未治疗的高血压对照组，但治疗组各级脑动脉损害和左心室肥厚明显改善，脑卒、中发生率也显著低于高血压对照组。结论美托洛尔抗高血压治疗预防脑卒中的效果，不单纯由血压下降决定，还与其具有保护脑血管和逆转心室肥厚等作用有关。

An experimental pathological study on stroke prevention by antihypertensive therapy with metroprolol

To investigate the morphological mechanisms of stroke prevention by antihypertensive therapy.Methods Stroke--prone renovascular hypertensive rats(RHRSP) were treated with metroprolol by oral for antihypertensive therapy. The morphological alterations of cerebral vascular lesions and cardiac ventricular wall thickness were observed in RHRSP. Results Although the blood pressure was lower slightly in treated HHRSP for a short period, the cerebral vascular lesions and hypertrophy of left vetricle improved obViously. The incidence of spontaneous stroke in beated group was significantly lower than that in non - treated group. Conclusions These results suggest that the effects of stroke prevention by antihypertensive therapy with metroprolol depend not only on the decrease of blood pressure, but also on the protection of cerebral vessels and the recovery of the left ventricular hypertrophy.