氟骨症患者心血管系统损害的研究

目的　了解终止接触氟后不同程度氟骨症患者心血管系统的损害。方法　选轻、中、重不同病情的氟骨症患者 65名和正常对照组 2 3人 ,详细询问受检者的心血管病史、测定血压并进行心电图检查。结果　氟骨症患者有心血管系统症状者占 70 .77% ,与对照组比较 ,差异显著 (P <0 .0 5 ) ;对各参数进行两两比较时发现随病情的加重有症状者的比率有上升的趋势 ,且对照组与重度组相比差异均有显著性 (P <0 .0 5 )。氟骨症组心电图异常 42例 ,检出率为 3 5 .3 8% ,对照组心电图异常 17例 ,检出率为 2 6.0 9% ,各组比较差异无显著性 (P >0 .0 5 )。心电图参数的比较 ,重度氟骨症组与对照组相比P -R间期明显延长且有差异 (P <0 .0 5 )。各调查组血压比较无差异 (P >0 .0 5 ) 。结论　氟骨症患者的心血管正常生理功能在改水降氟 18年以后仍然受到一定程度的干扰。在氟骨症患者中轻度和中度患者心电图的异常改变恢复明显 ,而重度氟骨症患者心电图的改变恢复缓慢 ,氟对重度氟骨症患者心电图的改变造成的远期影响 ,还有待于进一步的研究。

Study on the cardiovascular damage of skeletal fluorosis patients

Objective In order to comprehend the long-term effects on the cardiovascular damage of skeletal fluorosis patients after stopping exposure to excessive amount of fluoride.Methods 65 cases of the patients with different degree skeletal fluorosis,and 23 residents without skeletal fluorosis as contrast were surveyed in their history of cardioangiopathy and checked by blood pressure and electrocardiography. Results The skeletal fluorosis patients' abnormal rate of cardiovascular system symptom was 70.77%, but no different in statistics between patients and the control(P>0.05); The rate of cardiovascular system symptom has increasing with becoming heaver the disease degree of skeletal fluorosis, and the per-items' abnormal rates of the severe group were significantly higher than those of normal control (P<0.05). The abnormal rate of electrocardiogram (ECG) of the patient group was higher than that of normal control (42 cases,35.38%;17 cases 26.09%),but no different in statistics (P>0.05).The comparison of parameter of ECG shows that the P-R interval of the severe patients group were significantly longer than that of normal control (P<0.05).The blood pressure were no different in statistics(P>0.05) between patients with skeletal fluorosis and the control. Conclusions Fluorine has certain long-term hazardous effect on the patients' cardiovascular system although the patients with skeletal fluorosis had stopped drinking high fluoric water for eighteen years. The changes of ECG can be recovered in the mild skeletal fluorosis patients, but in the severe patients these changes recovered slower. Which kinds of long-term hazardous effect on the cardiovascular of the severe skeletal fluorosis patients,we still have a long way to go to catch up with.