睡眠剥夺条件下服用莫达芬尼对正常男性青年认知能力的影响

目的：观察48h睡眠剥夺（SD）条件下正常人服用新型中枢兴奋药莫达芬尼对提高认知能力的效果，为此药在我军飞行人员的进一步应用提供有关的试验依据。方法：6名健康男性青年志愿者，在两次SD试验（间隔两周）中交叉服用莫达芬尼和安慰剂，SD时间从第1日8：00至第3日8：00，于第2日0：00、16：00和第3日0：00分别服用莫达芬尼200mg或安慰剂，采用随机双盲设计给药，并在第1日21：00及每次服药后第1h、3h、5h和7h各完成1次认知能力测试：（1）4数连加：计算4个个位数相加的正确率；（2）心理运动：观察通过操纵杆控制计算机模拟的飞机飞行姿态的能力；（3）两者复合的双重任务。每阶段的试验数据用重复测量的两因素方差分析方法，分析各次服药后药物的主效应；再用两因素方差分析比较各个时间点药物与安慰剂的差别。结果：与安慰剂组比较，莫达芬尼能明显提高第2次服药后单、双重任务4数连加正确率，第3次服药后各项指标均较安慰剂组有显著提高（P＜0．05）。结论：莫达芬尼对SD条件下人体认知能力有明显的改善作用，使持续48h的工作绩效保持相对稳定的水平。

Effects of modafinil on cognitive ability of healthy young men during 48 h sleep deprivation

Objective To investigate the effects of modafinil, a new central stimulant, on cognitive ability during sleep deprivation(SD), and provide related information for its further use. Methods Six male healthy young volunteers underwent two 48 h SD test with 2 wk interval in a crossover design experiment. The SD started from 8:00 of the first day to 8:00 of the third day. Drug or placebo was given at 0:00, 16:00 of the second day and at 0:00 of the third day. Four digit addition(the correct rate of four digits addition), psychomotor performance(the ability of controlling the flying attitude of the airplane simulated by the computer) and dual task(the former two tasks combined together) were tested at 21:00 of the first day and 1, 3, 5, 7 h after drug administration. Data was processed with SPSS program. The main effect in each period was analyzed with repeated measures procedure, and the differences between modafinil group and placebo group at each time point with univariate procedure. Results Modafinil can markedly enhance the scores of psychomotor performance, four digit addition and dual task in comparison with placebo. The most noticeable benefits occurred after the third drug administration, when the combined impact of sleep loss and the circadian trough was most severe( P<0.05 ). Conclusions Modafinil can remarkably alleviate the deterioration of cognitive ability induced by sleep deprivation, and maintain cognitive performance at a relatively stable level.