Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson’s disease |
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Authors: | P M Mattila M Röyttä H Torikka D W Dickson J O Rinne |
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Institution: | (1) Department of Neurology, University of Turku, FIN-20520 Turku, Finland Tel.: 358-2-261-2700; Fax: 358-2-261-1709, FI;(2) Department of Pathology, University of Turku, Turku, Finland, FI;(3) Department of Biostatistics, University of Turku, Turku, Finland, FI;(4) Department of Pathology (Neuropathology), Albert Einstein College of Medicine, N.Y., USA, US |
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Abstract: | We investigated the role of cortical Lewy bodies (LB) and Alzheimer-type changes in cognitive impairment in patients with
idiopathic Parkinson’s disease (PD). We evaluated 44 cases for the extent of neuropathological lesions with a CERAD neuropathological
assessment battery and the stage of dementia using Reisberg’s global deterioration scale (GDS). Substantia nigra, amygdala,
hippocampus and cerebral cortex were examined for LB and Alzheimer-type changes. For detection of LB, the cortical areas
were stained with polyclonal antibodies against ubiquitin and tau. We found at least one cortical LB in 93% of cases. Furthermore,
43% of the cases had histological findings of definite Alzheimer’s disease (AD). The association between cognitive impairment
and the number of cortical LB and Alzheimer-type changes in the amygdala, hippocampus and six selected gyri from cerebral
cortex were analyzed using stepwise linear regression. In this analysis the total number of cortical LB, and the amount of
neurofibrillary tangles in the temporal cortex remained statistically significant. When the cases with neuropathological changes
consistent with a diagnosis of AD were excluded, the correlation between the total number of cortical LB and cognitive impairment
was more obvious. A stepwise linear regression analysis in these cases found the total number of cortical LB to be the statistically
significant predictor of cognitive impairment. This study revealed that LB densities in the cortex, especially in the temporal
neocortex, correlated significantly with the cognitive impairment in PD independent of or in addition to Alzheimer-type pathology.
Received: 18 August 1997 / Revised, accepted: 2 December 1997 |
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Keywords: | Alzheimer-type changes Cortical Lewy bodies Ubiquitin Parkinson’ s disease Dementia |
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