| 桔贝合剂质量标准研究 |
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| 引用本文： | 徐小利,姚丽佳,陈晓虎. 桔贝合剂质量标准研究[J]. 中国药业, 2009, 18(6): 29-30 |
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| 作者姓名： | 徐小利 姚丽佳 陈晓虎 |
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| 作者单位： | 重庆市药品检验所,重庆,401121 |
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| 摘 要： | 目的建立桔贝合剂的质量控制标准。方法用薄层色谱（TLC）法鉴别方中的浙贝母和枇杷叶，用高效液相色谱（HPLC）法测定制剂的黄芩苷含量。结果TLC法专属性强，黄芩苷进样量线性范围为0．02002～0．6006μg，r=0．9999（n=5），平均回收率为99．78％，RSD为1．30％（n=6）。结论定性定量方法简便、准确，重现性好，可作为桔贝合剂的质量控制标准。
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| 关 键 词： | 质量标准 桔贝合剂 黄芩苷 高效液相色谱法 薄层色谱法 |
Investigation of Quality Standard for Jubei Mixture |
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| Xu Xiaoli,Yao Lijia,Chen Xiaohu. Investigation of Quality Standard for Jubei Mixture[J]. China Pharmaceuticals, 2009, 18(6): 29-30 |
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| Authors: | Xu Xiaoli Yao Lijia Chen Xiaohu |
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| Affiliation: | ( Chongqing Institute For Drug Control, Chongqing, China 401121) |
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| Abstract: | Objective To establish the quality standard of Jubei Mixture. Methods To identify Bulbus Fritillariae Thunbergii and loquat leaf by TLC. Baicalin was determined by HPLC. Results The characteristic of identification by TLC was distinct and highly specific, the linear range of baicalin was 0. 020 02 -0. 600 6 μg, r=0. 999 9（ n =5）, the average recovery rate was 99.78%, RSD = 1.30% （ n =6）. Conclusion The method is easy to operate with accurate result and good reproducibility. It can be used effectively for the quality control of the preparation. |
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| Keywords: | quality standard Jubei Mixture baicalin HPLC TLC |
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