Antimicrobial susceptibility of 80 Moraxella catarrhalis strains isolated in the children's hospital of Tunis |
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| Authors: | Khemiri H Smaoui H Kechrid A |
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| Affiliation: | 1. Bone Marrow Transplant Department, Great Ormond Street Children Hospital, London, United Kingdom;2. Eurocord, Hopital Saint Louis and Hopital Saint Antoine, Paris, France;3. Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy;4. Stem Cell Transplant Unit, Hospital Niño Jesús, Madrid, Spain;5. Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium;6. Pediatric Hematology Oncology, Schneider Children''s Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel;7. Haematology, Birmingham Children''s Hospital, Birmingham, United Kingdom;8. Section of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium;9. Department of Pediatric Hematology/Oncology, G. Gaslini Children''s Research Institute, Genova, Italy;10. Serviço de Hematologia, Instituto Portugues de Oncologia, Lisboa, Portugal;11. Department of Pediatric Hematology/Oncology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia;12. Eurocord, Hopital Saint Louis, Paris, France;13. Centre Scientifique de Monaco, Principality of Monaco;14. Pediatric Blood and Bone Marrow Transplantation Program, University Medical Center Utrecht, Utrecht, Netherlands;15. Dipartimento di Onco-Ematologia Pediatrica e Medicina Trasfusionale, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Università di Pavia, Italy;16. Department of Pediatrics, University Medical Center Ulm, Ulm, Germany;17. Dept. of Paediatric Immunology, Newcastle General Hospital, Newcastle, United Kingdom;18. Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, North Carolina;19. Churchill Hospital, University of Oxford, NHS Blood and Transplant (NHSBT), Oxford, United Kingdom |
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| Abstract: | Eighty non-repetitive strains of Moraxella catarrhalis, isolated in Tunis Children's Hospital during five years from 1998 to 2002, were tested for their antimicrobial susceptibility, 95% of these strains were isolated from lung samples: 57.5% from trachea products, 35% from sputum and 2.5% from bronchial washings. The majority of strains (72%) were obtained from children under two years old. Antimicrobial susceptibility study showed that 95% of stains were beta-lactamase-producing, therefore they were penicillin G and amoxicillin resistant with high MICs. MIC(90) of penicillin G and amoxicillin of beta-lactamase-producing strains were respectively greater than 32 and 6 mg/l, these MIC decrease with addition of clavulanic acid. In fact, all strains studied were susceptible to the association amoxicillin-clavulanic acid as well as to cefotaxime. Concerning the other antimicrobial groups percentages of resistant strains found were as follows: erythromycin 3.75%, trimethoprim-sulfamethoxazol 12.5% and tetracycline 1.25%. Finally, all strains were susceptible to chloramphenicol, rifampicin and ciprofloxacin. |
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