急性脑梗死患者血清白介素-6、白介素-18水平与颈动脉内中膜厚度关系的探讨

目的 探讨急性脑梗死(ACI)患者血清细胞因子白介素-6(IL-6)、白介素-18(IL-18)水平与颈动脉内中膜厚度(IMT)的关系.方法 以64例ACI患者作为ACI组,30例健康体检者为正常对照组,利用放射免疫法(RIA)和酶联吸附法(ELISA)分别测定其血清IL-6和IL-18水平,分别测量其颈动脉内中膜厚度(IMT)值并分为IMT<1.0mm和IMT≥1.0mm两个亚组.结果 ACI组中IMT≥1.0mm者IL-6、IL-18含量与正常对照组相比差异有统计学意义(P<0.05),与IMT<1.0mm者相比差异亦有统计学意义(P<0.05).ACI组中IMT≥1.0mm者IMT与IL-18水平呈明显正相关(r=0.549,P=0.001),与IL-6水平无明显相关性(P>0.05).结论 ACI患者IMT增厚者血清IL-6、IL-18水平也升高.

Correlation of serum interleukin-6 and interleukin-18 levels to carotid artery intimal-medial thickness in patients with acute cerebral infarction

Objective To investigate the correlation of serum interleukin-6 (IL-6) and IL-18levels to carotid artery intimal-medial thickness (IMT) in patients with acute cerebral infarction (ACI).Methods In 64 patients with ACI and 30 healthy volunteers, serum IL-6 and IL-18 levels were detectedusing radioimmunoassay and enzyme-linked immunosorbent assay (ELISA), respectively. Carotid arteryIMT were measured in the two groups using color Doppler ultrasound, and the ACI patients were dividedinto two groups with carotid IMT greater or lower than 1.0 mm. Results The ACI patients and thehealthy volunteers showed significant differences in serum IL-6 (P<0.05) and IL-18 levels (P<0.05),which were also significantly different between ACI patients with carotid IMT ≥ 1.0 mm and those withIMT<1.0 mm (P<0.05). The ACI patients with IMT<1.0 mm had comparable serum IL-6 and IL-18 levelsto those in the healthy volunteers. In patients with carotid IMT ≥ 1.0 mm, the serum IL-18 level waspositively correlated to IMT (r=0.549, P=0.001), but the IL-6 level was not related to IMT (P>0.05).Conclusion The serum levels of IL-6 and IL-18 are elevated in ACI patients with increased carotid IMT.