Biological effects of aqueous extract from Turkey vulture Cathartes aura (Cathartidae) meat |
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| Authors: | Maria del Rosario Jacobo-Salcedo Maria del Carmen Juárez-Vázquez Luis Ángel González-Espíndola Sandra Patricia Maciel-Torres Alejandro García-Carrancá Angel Josabad Alonso-Castro |
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| Institution: | 1. Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Avenida Articulo 123, Fraccionamiento Filadelfia, Gómez Palacio, Durango 35010, México;2. Instituto Nacional de Cancerología, Av. San Fernando No. 22, Col. Sección XVI, Tlalpan, México D.F. 14080, México;3. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico;4. Facultad de Química, Universidad Nacional Autónoma de México México D.F. 04510, Mexico |
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| Abstract: | Ethnopharmacological relevanceCathartes aura is a bird used in the Mexican traditional medicine for the empirical treatment of cancer, injuries, infections and burns.Materials and methodsThe in vitro immunomodulatory effects of Cathartes aura extract (CAE) were evaluated estimating its effects on proliferation of human peripheral blood mononuclear cells and murine splenocytes. The effects of CAE (1–200 μg/ml) on NO production, pinocytosis and lysosomal enzyme activity were assayed in murine macrophages RAW 264.7. The cytotoxic effects of CAE (1–500 μg/ml) on tumorigenic and non tumorigenic cells were evaluated using the MTT assay.ResultsIn the absence of LPS, CAE induced the proliferation of murine splenocytes (119%), enhanced the pinocytosis (113%) and lysosomal enzyme activity (141%) in murine macrophages with a similar potency than lypopolisaccharides 1 μg/ml. In addition, CAE exerted cytotoxic effects mainly on human cervical cancer cells (IC50=117 μg/ml) but lacked toxic effects on non tumorigenic cells (IC50>500 μg/ml).ConclusionCathartes aura exerts immunostimulatory and cytotoxic activities |
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| Keywords: | Immunostimulatory Cancer Cytotoxic |
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