Modulation of stability and mucoadhesive properties of chitosan microspheres for therapeutic gastric application |
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| Authors: | Mariana Fernandes,Inê s C. Gonç alves,Stefania Nardecchia,Isabel F. Amaral,Má rio A. Barbosa,M. Cristina L. Martins |
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| Affiliation: | 1. INEB – Instituto de Engenharia Biomédica, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal;2. IPATIMUP – Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;3. Universidade do Porto, Faculdade de Engenharia, Porto, Portugal;4. Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal |
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| Abstract: | Chitosan microspheres have been explored for pharmaceutical applications, namely as a drug delivery systems for Helicobacter pylori gastric infection treatment, due to their mucoadhesive capacity. In this study, a different application of chitosan microspheres is proposed aiming the creation of an H. pylori-binding system where, after oral administration, microspheres will capture and remove these bacteria from infected patients, taking advantage of their muco/bacterial adhesive process. However, mucoadhesion is influenced by the degree of crosslinking necessary to avoid microspheres dissolution in the acidic gastric environment. |
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| Keywords: | Microspheres Chitosan Genipin Mucoadhesion Biomaterials Helicobacter pylori |
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