Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar |
| |
Authors: | Dayane Carla Costa Paiva Cliomar Alves dos Santos Jaécio Carlos Diniz Francisco Arnaldo Viana Sara Maria Thomazzi Dayseanne Araujo Falcão |
| |
Institution: | 1. Universidade do Estado do Rio Grande do Norte—Av. Prof. Antônio Campos, s/n, 59633-010 Mossoró/RN, Brazil;2. Universidade Federal de Sergipe—Av. Marechal Rondon, s/n, 49100-000 São Cristóvão/SE, Brazil |
| |
Abstract: | Ethnopharmacological relevanceThe Pseudobombax marginatum (St Hil) Rob., Malvaceae, is mentioned in ethnobotanical studies. It is used as anti-inflammatory, for ulcers and gastritis, and back pain. To evaluate anti-inflammatory and antinociceptive activities a hydroalcoholic extract (HE) from inner bark was prepared.Materials and methodsFor the anti-inflammatory activity, carrageenan-induced paw edema and peritonitis models, and also myeloperoxidase assay were used. For the antinociceptiva activity acetic acid-induced writhing, hot plate and formalin tests were employed.ResultsThe HE extract exhibited an intense inhibition in carrageenan-induced edema model and also in myeloperoxidase activity at the doses of 100 and 300 mg/kg. The leukocyte migration into the peritoneal cavity was also inhibited at the doses of 30, 100 and 300 mg/kg. A similar profile was observed against acid-induced abdominal contortions and in formalin second phase test at the doses of 30 and 100 mg/kg, but this treatment did not affect the behavior of animals in the hot plate test.ConclusionsThe experimental data of the HE from Pseudobombax marginatum show anti-inflammatory and antinociceptiva activities, confirming the indication from traditional medicine; however further studies are required to define and isolate the active anti-inflammatory and antinociceptiva components from this active specie. |
| |
Keywords: | ANOVA analysis of variance APG group phylogeny of angiosperms ASA acetylsalicylic acid AUC area under curves CEPA ethics committee for animal use in research COX cyclo-oxygenase EDTA ethylenediaminetetraacetic acid FLONA national forest HE hydroalcoholic extract MPO myeloperoxidase NO nitric oxide PGs prostaglandins PGE2 prostaglandin E2 SISBIO authorization system and information in biodiversity UMPO units of myeloperoxidase |
本文献已被 ScienceDirect 等数据库收录! |
|