Effect of surface chemistry of porous silicon microparticles on glucagon-like peptide-1 (GLP-1) loading,release and biological activity |
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| Authors: | Anne Huotari,Wujun Xu,Juha Mö nkä re,Miia Kovalainen,Karl-Heinz Herzig,Vesa-Pekka Lehto,Kristiina Jä rvinen |
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| Affiliation: | 1. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland;2. Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland;3. Institute of Biomedicine & Biocenter of Oulu, University of Oulu, 90014 Oulu, Finland;4. Department of Psychiatry, Kuopio University Hospital, 70211 Kuopio, Finland |
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| Abstract: | ![]()
Recently, mesoporous silicon (PSi) microparticles have been shown to extend the duration of action of peptides, reducing the need for frequent injections. Glucagon-like peptide 1 (GLP-1) is a potential novel treatment for type 2 diabetes. |
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| Keywords: | In vivo Mesoporous silicon Peptide delivery GLP-1 Blood glucose levels |
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