Her-2、TopoⅡα和激素受体在乳腺癌中的表达及意义

目的探讨Her-2、TopoⅡα、ER和PR在乳腺癌中的表达及临床意义。方法免疫组织化学检测80例乳腺癌组织中Her-2、TopoⅡα、ER和PR的表达情况,并进行统计学分析。结果80例乳腺癌ER、PR、Her-2及TopoⅡα表达阳性率分别为72.5%、62.5%、30%和86.3%;Her-2及TopoⅡα随着临床分期增加和腋窝淋巴结转移数目的增加,其阳性表达率亦增加,且有显著性差异(P<0.05)。ER、PR阳性表达率则相反,无显著性差异(P>0.05)。ER、PR阳性表达率与Her-2及TopoⅡα阳性表达呈负相关(P>0.05)。结论联合检测Her-2、TopoⅡα、ER和PR,对于乳腺癌的治疗具有指导意义,也是判断预后的重要指标。

Expression of Her-2,TopoⅡα and the hormone receptor in breast carcinoma and their clinical significances

Objective To study the expression levels of estrogen receptor(ER),progesterone receptor(PR),Her-2 and TopoⅡα as well as their correlations and clinical significances in breast cancer tissues.Methods The assays of ER,PR,Her-2 and TopoⅡα were performed by immunohistochemical SP methods on the paraffin routinely embedded sections of specimens from breast cancer tissue.Results The positivity expression rates of ER,PR,Her-2 and TopoⅡα were 72.5%,62.5%,30% and 86.3%,respectively.The positivity rates of Her-2 and TopoⅡα increased with the number of metastasis lymph node and clinical stage,and there was a significant correlation(P<0.05).The positivity rates of ER and PR decreased with the number of metastasis lymph node and clinical stage,and there wasn't significant correlation(P>0.05).ER and PR had a reverse correlation with the expression of Her-2 and TopoⅡα,but there wasn't significant difference(P>0.05).Conclusion Her-2 and TopoⅡα are useful prognostic factors in patients with breast cancer.The expression of ER and PR are associated with the clinical stage and lymph node metastases of breast cancer.