深圳市2005年、2009年结核菌耐药监测结果

目的了解深圳市结核分枝杆菌耐药情况，为深圳市结核病控制提供科学依据。方法依据（WHO／IUALD）结核病耐药指南，将深圳市2005年和2009年每年3月至8月间所有新涂阳和新登记的复治涂阳的肺结核作为监测对象，对2005年802例、2009年1054例成功分离的结核分枝杆菌菌株，用比例法进行药物敏感实验。结果2005年总耐药率18．3％，初始耐药率17．2％，获得性耐药率31．3％；总耐多药率4．7％，初始和获得性耐多药率分别为3．25％和21．9％；2009年总耐药率17．4％，初始耐药率16％，获得性耐药率39．3％；总耐多药率3．8％，初始和获得性耐多药率分别为3．02％和16．4％。2009年以上各耐药率、各耐多药率与2005年比较，差异元统计学意义，2005年、2009年的获得性耐药率、获得性耐多药率均显著高于初始耐药率、初始耐多药率。结论深圳市耐药结核病的发生率处于较高水平，应该引起高度重视。

Comparative analysis of 2005,2009 tuberculosis drug resistance surveillance in Shenzhen

Objective To understand the situation of drug resistance( DR) and multi-drug resistance( MDRTB) tuberculosis in Shenzhen and provide scientific evidence for TB control in Shenzhen. Methods According to drug resistance TB guidelines issued by WHO/IUALD, all new smear positive cases and.new registered retreatment smear positive cases in 2005 and 2009 were included in the surveillance. A total of 1856 strains of mycobacterium tuberculosis were isolated and drug susceptibility test were performed with the proportional method. Results In 2005, the overall DR rate was 18. 3% , 17. 2% and 31. 3% for initial and acquired DR respectively, overall MDR rate was 4. 74% ,3.25% and 21.9% respectively for initial and acquired MDR. In 2009, the overall DR rate was 17.4% , 16% and 39. 3%for initial and acquired DR respectively,overall MDR rate was 3.8% ,3.02% and 16.4% respectively for initial and acquired MDR. In 2005,2009, the rates of acquired DR and acquired MDR were significantly higher than the rates of initial DR and initial MDR. Conclusion The incidence of TB drug resistance in Shenzhen was high and merits attention.